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Amytrapper Catheter Capture Aβ42 From Whole Blood in vivo in AD Rats. (A) Aβ42 From AD Rat Whole Blood Bound to Amytrapper Coated and Control Uncoated (Mock) Catheters at the End of the Treatment. After Treatment, Amytrapper Catheters and Mock Catheters Were Used for the Measurement of Catheter-Bound Aβ Through Designed Immunosorbent Assay. The Experiment Aimed to Determine the Effectiveness of Amytrapper-Coated Catheters in Capturing Aβ42 From the Bloodstream. Statistically Significant Difference Between the Mock Catheter (n = 20 Assay) and Amytrapper Catheter Treatment Groups (n = 41 Assay) is Expressed as *** P < 0.001, Cohen’s d = 3.496416, Utilizing Unpaired T-test. (B) Plasma Aβ42 From Rats before and after Catheter Treatments as Measured by Sensolyte® Quantitative ELISA kit. Plasma Aβ42 Levels before Mock Catheter (n = 7) or Amytrapper Catheter Treatment (n = 16) are Displayed as Blue Columns. Plasma Aβ42 Levels after third Mock Catheter (n = 6) or Amytrapper Catheter Treatment (n = 14) are Displayed as Yellow Columns. Plasma Aβ42 Levels after sixth Mock Catheter (n = 5) or Amytrapper Catheter Treatment (n = 6) are Displayed as Orange Columns. Statistically Significant Difference is Arrived by Comparing the Same Treatment (third Treatment and sixth Treatment) Between Mock Catheter Groups and Amytrapper Catheter Groups Using the Unpaired T-test. Statistically Significant Difference Between the Mock and Amytrapper Catheter Treatment Groups is Expressed (* P < 0.05, ** P < 0.01 Utilizing Unpaired T-test)

Journal: American Journal of Alzheimer's Disease and Other Dementias

Article Title: Amytrapper Catheter: A Prototype Extracorporeal Device That Traps Blood Amyloid-β in a Rat Model of Alzheimer’s Disease

doi: 10.1177/15333175251361265

Figure Lengend Snippet: Amytrapper Catheter Capture Aβ42 From Whole Blood in vivo in AD Rats. (A) Aβ42 From AD Rat Whole Blood Bound to Amytrapper Coated and Control Uncoated (Mock) Catheters at the End of the Treatment. After Treatment, Amytrapper Catheters and Mock Catheters Were Used for the Measurement of Catheter-Bound Aβ Through Designed Immunosorbent Assay. The Experiment Aimed to Determine the Effectiveness of Amytrapper-Coated Catheters in Capturing Aβ42 From the Bloodstream. Statistically Significant Difference Between the Mock Catheter (n = 20 Assay) and Amytrapper Catheter Treatment Groups (n = 41 Assay) is Expressed as *** P < 0.001, Cohen’s d = 3.496416, Utilizing Unpaired T-test. (B) Plasma Aβ42 From Rats before and after Catheter Treatments as Measured by Sensolyte® Quantitative ELISA kit. Plasma Aβ42 Levels before Mock Catheter (n = 7) or Amytrapper Catheter Treatment (n = 16) are Displayed as Blue Columns. Plasma Aβ42 Levels after third Mock Catheter (n = 6) or Amytrapper Catheter Treatment (n = 14) are Displayed as Yellow Columns. Plasma Aβ42 Levels after sixth Mock Catheter (n = 5) or Amytrapper Catheter Treatment (n = 6) are Displayed as Orange Columns. Statistically Significant Difference is Arrived by Comparing the Same Treatment (third Treatment and sixth Treatment) Between Mock Catheter Groups and Amytrapper Catheter Groups Using the Unpaired T-test. Statistically Significant Difference Between the Mock and Amytrapper Catheter Treatment Groups is Expressed (* P < 0.05, ** P < 0.01 Utilizing Unpaired T-test)

Article Snippet: SensoLyte anti-human Aβ42 quantitative ELISA colorimetric kit (Anaspec, Fremont, CA) was used to estimate the amount of Aβ42 in plasma and CSF in rats.

Techniques: In Vivo, Control, Clinical Proteomics, Enzyme-linked Immunosorbent Assay

Cerebrospinal Fluid Aβ42 Levels in Mock and Amytrapper Catheter-Treated AD Rats. CSF Aβ42 From Rats before and after Catheter Treatments was Measured Using the Sensolyte® Quantitative ELISA kit. Following Two Months of Treatment, Rats Treated With the Amytrapper Catheter (n = 6) Displayed Slightly Higher Levels of Aβ42 in the CSF Compared to the Mock Catheter (n = 5) as Control Group ( P > 0.05; n.s, Utilizing Unpaired T-test)

Journal: American Journal of Alzheimer's Disease and Other Dementias

Article Title: Amytrapper Catheter: A Prototype Extracorporeal Device That Traps Blood Amyloid-β in a Rat Model of Alzheimer’s Disease

doi: 10.1177/15333175251361265

Figure Lengend Snippet: Cerebrospinal Fluid Aβ42 Levels in Mock and Amytrapper Catheter-Treated AD Rats. CSF Aβ42 From Rats before and after Catheter Treatments was Measured Using the Sensolyte® Quantitative ELISA kit. Following Two Months of Treatment, Rats Treated With the Amytrapper Catheter (n = 6) Displayed Slightly Higher Levels of Aβ42 in the CSF Compared to the Mock Catheter (n = 5) as Control Group ( P > 0.05; n.s, Utilizing Unpaired T-test)

Article Snippet: SensoLyte anti-human Aβ42 quantitative ELISA colorimetric kit (Anaspec, Fremont, CA) was used to estimate the amount of Aβ42 in plasma and CSF in rats.

Techniques: Enzyme-linked Immunosorbent Assay, Control